2afw: Difference between revisions

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[[Image:2afw.gif|left|200px]]<br /><applet load="2afw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2afw.gif|left|200px]]
caption="2afw, resolution 1.56&Aring;" />
 
'''crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine'''<br />
{{Structure
|PDB= 2afw |SIZE=350|CAPTION= <scene name='initialview01'>2afw</scene>, resolution 1.56&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=AHN:N-[2-(1H-IMIDAZOL-4-YL)ETHYL]ACETAMIDE'>AHN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutaminyl-peptide_cyclotransferase Glutaminyl-peptide cyclotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.5 2.3.2.5]
|GENE= QPCT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AFW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=AHN:'>AHN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutaminyl-peptide_cyclotransferase Glutaminyl-peptide cyclotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.5 2.3.2.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFW OCA].  
2AFW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFW OCA].  


==Reference==
==Reference==
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation., Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH, Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13117-22. Epub 2005 Aug 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16135565 16135565]
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation., Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH, Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13117-22. Epub 2005 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16135565 16135565]
[[Category: Glutaminyl-peptide cyclotransferase]]
[[Category: Glutaminyl-peptide cyclotransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: metalloprotein]]
[[Category: metalloprotein]]


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