4j5p: Difference between revisions
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{{STRUCTURE_4j5p| PDB=4j5p | SCENE= }} | |||
===Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase=== | |||
{{ABSTRACT_PUBMED_23581831}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |||
==About this Structure== | |||
[[4j5p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5P OCA]. | |||
[[Category: Fatty acid amide hydrolase]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Boger, D L.]] | |||
[[Category: Brown, M.]] | |||
[[Category: Cravatt, B F.]] | |||
[[Category: Han, G W.]] | |||
[[Category: Lichtman, A H.]] | |||
[[Category: McCormick, M S.]] | |||
[[Category: Neal, S T.O.]] | |||
[[Category: Otrubova, K.]] | |||
[[Category: Stevens, R C.]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 10:40, 2 May 2013
Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide HydrolaseCrystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase
Template:ABSTRACT PUBMED 23581831
FunctionFunction
[FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
About this StructureAbout this Structure
4j5p is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.