4j5l: Difference between revisions
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{{STRUCTURE_4j5l| PDB=4j5l | SCENE= }} | |||
===Structure of the Cargo Binding Domain from Human Myosin Va=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref> | |||
==About this Structure== | |||
[[4j5l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5L OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Assis, L H.P.]] | |||
[[Category: Berridge, G.]] | |||
[[Category: Burgess-Brown, N.]] | |||
[[Category: Delft, F von.]] | |||
[[Category: Krojer, T.]] | |||
[[Category: Mahajan, P.]] | |||
[[Category: Murakami, M T.]] | |||
[[Category: Nascimento, A F.Z.]] | |||
[[Category: Tonoli, C C.C.]] | |||
[[Category: Trindade, D M.]] | |||
[[Category: Vollmar, M.]] | |||
[[Category: C-terminal globular tail]] | |||
[[Category: Human myosin va]] | |||
[[Category: Intracellular traffic]] | |||
[[Category: Protein transport]] | |||
[[Category: Vesicle]] | |||
Revision as of 09:38, 10 October 2013
Structure of the Cargo Binding Domain from Human Myosin VaStructure of the Cargo Binding Domain from Human Myosin Va
DiseaseDisease
[MYO5A_HUMAN] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
FunctionFunction
[MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.[1]
About this StructureAbout this Structure
4j5l is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Mehta AD, Rock RS, Rief M, Spudich JA, Mooseker MS, Cheney RE. Myosin-V is a processive actin-based motor. Nature. 1999 Aug 5;400(6744):590-3. PMID:10448864 doi:http://dx.doi.org/10.1038/23072