4j34: Difference between revisions
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{{STRUCTURE_4j34| PDB=4j34 | SCENE= }} | |||
===Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.<ref>PMID:12062417</ref> <ref>PMID:15806102</ref> | |||
==About this Structure== | |||
[[4j34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J34 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Kynurenine 3-monooxygenase]] | |||
[[Category: Saccharomyces cerevisiae s288c]] | |||
[[Category: Amaral, M.]] | |||
[[Category: Giorgini, F.]] | |||
[[Category: Heyes, D J.]] | |||
[[Category: Lafite, P.]] | |||
[[Category: Levy, C.]] | |||
[[Category: Leys, D.]] | |||
[[Category: Outeiro, T F.]] | |||
[[Category: Scrutton, N S.]] | |||
[[Category: Monooxygenase kynurenine his cleaved]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 01:49, 11 April 2013
Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.
FunctionFunction
[KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.[1] [2]
About this StructureAbout this Structure
4j34 is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 2002 Apr 24;517(1-3):97-102. PMID:12062417
- ↑ Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet. 2005 May;37(5):526-31. Epub 2005 Apr 3. PMID:15806102 doi:ng1542