4iy5: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4iy5|  PDB=4iy5  |  SCENE=  }}
+===Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution===
+{{ABSTRACT_PUBMED_23999288}}
-The entry 4iy5 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
-Authors: Krintel, C., Frydenvang, K., Harpsoe, K., Gajhede, M., Kastrup, J.S
+==About this Structure==
+[[4iy5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY5 OCA].
-Description: Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution
+==Reference==
+<ref group="xtra">PMID:023999288</ref><references group="xtra"/><references/>
+[[Category: Rattus norvegicus]]
+[[Category: Frydenvang, K.]]
+[[Category: Gajhede, M.]]
+[[Category: Harpsoe, K.]]
+[[Category: Kastrup, J S.]]
+[[Category: Krintel, C.]]
+[[Category: Allosteric modulation]]
+[[Category: Ampa receptor ligand-binding domain]]
+[[Category: Cx516]]
+[[Category: Glua2 s1s2j-l483y-n754]]
+[[Category: Membrane protein]]