2m4h: Difference between revisions
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{{STRUCTURE_2m4h| PDB=2m4h | SCENE= }} | |||
===Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein=== | |||
{{ABSTRACT_PUBMED_23487472}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/POLG_FCVF9 POLG_FCVF9]] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity). Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity). | |||
==About this Structure== | |||
[[2m4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Feline_calicivirus_(strain_f9) Feline calicivirus (strain f9)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M4H OCA]. | |||
[[Category: Birtley, J R.]] | |||
[[Category: Curry, S.]] | |||
[[Category: Kwok, R N.]] | |||
[[Category: Leen, E N.]] | |||
[[Category: Marchant, J.]] | |||
[[Category: Matthews, S.]] | |||
[[Category: Prater, S N.]] | |||
[[Category: Simpson, P J.]] | |||
[[Category: Ns5]] | |||
[[Category: Viral protein]] | |||
[[Category: Vpg]] | |||
Revision as of 11:51, 27 March 2013
Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg proteinSolution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein
Template:ABSTRACT PUBMED 23487472
FunctionFunction
[POLG_FCVF9] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity). Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
About this StructureAbout this Structure
2m4h is a 1 chain structure with sequence from Feline calicivirus (strain f9). Full experimental information is available from OCA.