2a11: Difference between revisions
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[[Image:2a11.gif|left|200px]] | [[Image:2a11.gif|left|200px]] | ||
'''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis''' | {{Structure | ||
|PDB= 2a11 |SIZE=350|CAPTION= <scene name='initialview01'>2a11</scene>, resolution 2.100Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] | |||
|GENE= rnc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis]) | |||
}} | |||
'''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2A11 is a [ | 2A11 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A11 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:[http:// | Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16155207 16155207] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Ribonuclease III]] | [[Category: Ribonuclease III]] | ||
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[[Category: protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)]] | [[Category: protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)]] | ||
[[Category: psi]] | [[Category: psi]] | ||
[[Category: ribonuclease; rnase iii; nuclease domain; structural | [[Category: ribonuclease; rnase iii; nuclease domain; structural genomic]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:44:07 2008'' | ||
Revision as of 16:44, 20 March 2008
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| , resolution 2.100Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | rnc (Mycobacterium tuberculosis) | ||||||
| Activity: | Ribonuclease III, with EC number 3.1.26.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis
OverviewOverview
RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.
About this StructureAbout this Structure
2A11 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207
Page seeded by OCA on Thu Mar 20 15:44:07 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Mycobacterium tuberculosis
- Ribonuclease III
- Single protein
- Akey, D L.
- Berger, J M.
- XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.
- CA
- Protein structure initiative; mycobacterium tuberculosis structural proteomics project (xmtb)
- Psi
- Ribonuclease; rnase iii; nuclease domain; structural genomic