3vzd: Difference between revisions
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{{STRUCTURE_3vzd| PDB=3vzd | SCENE= }} | |||
===Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP=== | |||
{{ABSTRACT_PUBMED_23602659}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref> | |||
==About this Structure== | |||
[[3vzd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZD OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Sphinganine kinase]] | |||
[[Category: Min, X.]] | |||
[[Category: Walker, N P.]] | |||
[[Category: Wang, Z.]] | |||
[[Category: Lipid kinase]] | |||
[[Category: Transferase-inhibitor complex]] | |||
Revision as of 10:36, 2 May 2013
Crystal structure of Sphingosine Kinase 1 with inhibitor and ADPCrystal structure of Sphingosine Kinase 1 with inhibitor and ADP
Template:ABSTRACT PUBMED 23602659
FunctionFunction
[SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.[1]
About this StructureAbout this Structure
3vzd is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128. PMID:20577214 doi:10.1038/nature09128