2iu0: Difference between revisions
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{{STRUCTURE_2iu0| PDB=2iu0 | SCENE= }} | {{STRUCTURE_2iu0| PDB=2iu0 | SCENE= }} | ||
===crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase=== | |||
=== | |||
{{ABSTRACT_PUBMED_17324932}} | {{ABSTRACT_PUBMED_17324932}} | ||
==About this Structure== | ==About this Structure== | ||
[[2iu0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IU0 OCA]. | [[2iu0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b0w 2b0w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IU0 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 20: | Line 16: | ||
[[Category: Li, C.]] | [[Category: Li, C.]] | ||
[[Category: Olson, A J.]] | [[Category: Olson, A J.]] | ||
[[Category: Onofrio, A D | [[Category: Onofrio, A D]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
[[Category: Xu, L.]] | [[Category: Xu, L.]] | ||
Revision as of 12:10, 13 March 2013
crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolasecrystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
Template:ABSTRACT PUBMED 17324932
About this StructureAbout this Structure
2iu0 is a 2 chain structure with sequence from Gallus gallus. This structure supersedes the now removed PDB entry 2b0w. Full crystallographic information is available from OCA.
ReferenceReference
[xtra 1][xtra 2][xtra 3][xtra 4][xtra 5][xtra 6][xtra 7][xtra 8]
- ↑ Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282(17):13033-46. Epub 2007 Feb 26. PMID:17324932 doi:10.1074/jbc.M607293200
- ↑ Xu L, Li C, Olson AJ, Wilson IA. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J Biol Chem. 2004 Nov 26;279(48):50555-65. Epub 2004 Sep 7. PMID:15355974 doi:10.1074/jbc.M406801200
- ↑ Li C, Xu L, Wolan DW, Wilson IA, Olson AJ. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. J Med Chem. 2004 Dec 30;47(27):6681-90. PMID:15615517 doi:10.1021/jm049504o
- ↑ Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nat Struct Biol. 2001 May;8(5):402-6. PMID:11323713 doi:http://dx.doi.org/10.1038/87555
- ↑ Wolan DW, Greasley SE, Beardsley GP, Wilson IA. Structural insights into the avian AICAR transformylase mechanism. Biochemistry. 2002 Dec 31;41(52):15505-13. PMID:12501179
- ↑ Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 2003 Sep 23;42(37):10904-14. PMID:12974624 doi:http://dx.doi.org/10.1021/bi030106h
- ↑ Wolan DW, Cheong CG, Greasley SE, Wilson IA. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. Biochemistry. 2004 Feb 10;43(5):1171-83. PMID:14756553 doi:10.1021/bi030162i
- ↑ Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200