2i3s: Difference between revisions
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{{STRUCTURE_2i3s| PDB=2i3s | SCENE= }} | {{STRUCTURE_2i3s| PDB=2i3s | SCENE= }} | ||
===Bub3 complex with Bub1 GLEBS motif=== | ===Bub3 complex with Bub1 GLEBS motif=== | ||
{{ABSTRACT_PUBMED_17227844}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BUB3_YEAST BUB3_YEAST]] Required for cell cycle arrest in response to loss of microtubule function. Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.<ref>PMID:15879521</ref> [[http://www.uniprot.org/uniprot/BUB1_YEAST BUB1_YEAST]] Involved in cell cycle checkpoint enforcement. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism. Catalyzes the phosphorylation of BUB3 and its autophosphorylation. Associates with centromere (CEN) DNA via interaction with SKP1. The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.<ref>PMID:12769845</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2i3s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2i3s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3S OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017227844</ref>< | <ref group="xtra">PMID:017227844</ref><references group="xtra"/><references/> | ||
[[Category: Atcc 18824]] | |||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Harrison, S C.]] | [[Category: Harrison, S C.]] | ||
[[Category: Larsen, N A.]] | [[Category: Larsen, N A.]] | ||