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{{STRUCTURE_4ijo| PDB=4ijo | SCENE= }} | |||
===Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases=== | |||
{{ABSTRACT_PUBMED_23583775}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | |||
==About this Structure== | |||
[[4ijo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJO OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:017096442</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Macrophage elastase]] | |||
[[Category: Arad-Yellin, R.]] | |||
[[Category: Berezovsky, I N.]] | |||
[[Category: Calderone, V.]] | |||
[[Category: Fragai, M.]] | |||
[[Category: Grossman, M.]] | |||
[[Category: Luchinat, C.]] | |||
[[Category: Melikian, M.]] | |||
[[Category: Mitternacht, S.]] | |||
[[Category: Sagi, I.]] | |||
[[Category: Toccafondi, M.]] | |||
[[Category: Udi, Y.]] | |||
[[Category: Amphiphol]] | |||
[[Category: Degradation of the extracellular matrix protein]] | |||
[[Category: Extracellular]] | |||
[[Category: Hydrolase]] | |||
[[Category: Matrix metalloproteinase]] | |||
[[Category: Regulatory site]] | |||
Revision as of 10:37, 2 May 2013
Template:ABSTRACT PUBMED 23583775
FunctionFunction
[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
About this StructureAbout this Structure
4ijo is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ. Snapshots of the reaction mechanism of matrix metalloproteinases. Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442 doi:10.1002/anie.200603100