3w4j: Difference between revisions
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{{STRUCTURE_3w4j| PDB=3w4j | SCENE= }} | |||
===Crystal Structure of human DAAO in complex with coumpound 12=== | |||
{{ABSTRACT_PUBMED_23566269}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref> | |||
==About this Structure== | |||
[[3w4j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4J OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023566269</ref><references group="xtra"/><references/> | |||
[[Category: D-amino-acid oxidase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Hamajima, T.]] | |||
[[Category: Harada, K.]] | |||
[[Category: Hondo, T.]] | |||
[[Category: Matsumoto, Y.]] | |||
[[Category: Nakanishi, K.]] | |||
[[Category: Namatame, I.]] | |||
[[Category: Niimi, T.]] | |||
[[Category: Orita, M.]] | |||
[[Category: Sakashita, H.]] | |||
[[Category: Takeuchi, M.]] | |||
[[Category: Warizaya, M.]] | |||
[[Category: Watanabe, T.]] | |||
[[Category: Yamaguchi, T.]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
Revision as of 18:48, 19 June 2013
Crystal Structure of human DAAO in complex with coumpound 12Crystal Structure of human DAAO in complex with coumpound 12
Template:ABSTRACT PUBMED 23566269
FunctionFunction
[OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]
About this StructureAbout this Structure
3w4j is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hondo T, Warizaya M, Niimi T, Namatame I, Yamaguchi T, Nakanishi K, Hamajima T, Harada K, Sakashita H, Matsumoto Y, Orita M, Takeuchi M. 4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors. J Med Chem. 2013 May 9;56(9):3582-92. doi: 10.1021/jm400095b. Epub 2013 Apr 25. PMID:23566269 doi:10.1021/jm400095b
- ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181