1h52: Difference between revisions

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OCA

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-[[Image:1h52.png|left|200px]]
 {{STRUCTURE_1h52|  PDB=1h52  |  SCENE=  }}
+===BINDING OF PHOSPHATE AND PYROPHOSPHATE IONS AT THE ACTIVE SITE OF HUMAN ANGIOGENIN AS REVEALED BY X-RAY CRYSTALLOGRAPHY===
+{{ABSTRACT_PUBMED_11468363}}
-===BINDING OF PHOSPHATE AND PYROPHOSPHATE IONS AT THE ACTIVE SITE OF HUMAN ANGIOGENIN AS REVEALED BY X-RAY CRYSTALLOGRAPHY===
+==Disease==
+[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[http://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref><ref>PMID:15557516</ref><ref>PMID:16501576</ref><ref>PMID:17900154</ref><ref>PMID:18087731</ref><ref>PMID:17703939</ref>
-{{ABSTRACT_PUBMED_11468363}}
+==Function==
+[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref><ref>PMID:19354288</ref>
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:011468363</ref><ref group="xtra">PMID:009918722</ref><references group="xtra"/>
+<ref group="xtra">PMID:011468363</ref><ref group="xtra">PMID:009918722</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Acharya, K R.]]