4ij8: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4ij8| PDB=4ij8 | SCENE= }} | {{STRUCTURE_4ij8| PDB=4ij8 | SCENE= }} | ||
===Crystal structure of the complex of SETD8 with SAM=== | ===Crystal structure of the complex of SETD8 with SAM=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/SETD8_HUMAN SETD8_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4ij8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4ij8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJ8 OCA]. | ||
[[Category: | |||
[[Category: | ==See Also== | ||
*[[Histone methyltransferase|Histone methyltransferase]] | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Human]] | |||
[[Category: Miscellaneous nucleic acid]] | |||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
[[Category: Bakkouri, M El.]] | [[Category: Bakkouri, M El.]] | ||