4ihc: Difference between revisions

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[[Image:4ihc.jpg|left|200px]]
==Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703==
 
<StructureSection load='4ihc' size='340' side='right' caption='[[4ihc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
{{STRUCTURE_4ihc|  PDB=4ihc  |  SCENE=  }}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ihc]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Dickeya_dadantii_ech703 Dickeya dadantii ech703]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IHC FirstGlance]. <br>
===Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703===
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dd703_0947 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=579405 Dickeya dadantii Ech703])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ihc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ihc RCSB], [http://www.ebi.ac.uk/pdbsum/4ihc PDBsum]</span></td></tr>
==About this Structure==
</table>
[[4ihc]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Dickeya_dadantii_ech703 Dickeya dadantii ech703]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHC OCA].  
== Function ==
[[http://www.uniprot.org/uniprot/C6CBG9_DICDC C6CBG9_DICDC]] Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds. Has no detectable activity with a panel of 70 other acid sugars (in vitro).<ref>PMID:24697546</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dickeya dadantii ech703]]
[[Category: Dickeya dadantii ech703]]
[[Category: Almo, S C.]]
[[Category: Almo, S C]]
[[Category: Bhosle, R.]]
[[Category: Bhosle, R]]
[[Category: Chowdhury, S.]]
[[Category: Chowdhury, S]]
[[Category: EFI, Enzyme Function Initiative.]]
[[Category: EFI, Enzyme Function Initiative]]
[[Category: Evans, B.]]
[[Category: Evans, B]]
[[Category: Gerlt, J A.]]
[[Category: Gerlt, J A]]
[[Category: Glenn, A Scott.]]
[[Category: Glenn, A Scott]]
[[Category: Hammonds, J.]]
[[Category: Hammonds, J]]
[[Category: Hillerich, B.]]
[[Category: Hillerich, B]]
[[Category: Imker, H J.]]
[[Category: Imker, H J]]
[[Category: Love, J.]]
[[Category: Love, J]]
[[Category: Obaidi, N F.Al.]]
[[Category: Obaidi, N F.Al]]
[[Category: Patskovsky, Y.]]
[[Category: Patskovsky, Y]]
[[Category: Seidel, R D.]]
[[Category: Seidel, R D]]
[[Category: Stead, M.]]
[[Category: Stead, M]]
[[Category: Toro, R.]]
[[Category: Toro, R]]
[[Category: Washington, E.]]
[[Category: Washington, E]]
[[Category: Zencheck, W D.]]
[[Category: Zencheck, W D]]
[[Category: Dehydratase]]
[[Category: Dehydratase]]
[[Category: Efi]]
[[Category: Efi]]

Revision as of 15:57, 4 January 2015

Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703

Structural highlights

4ihc is a 8 chain structure with sequence from Dickeya dadantii ech703. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Gene:Dd703_0947 (Dickeya dadantii Ech703)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[C6CBG9_DICDC] Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds. Has no detectable activity with a panel of 70 other acid sugars (in vitro).[1]

References

  1. ↑ Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA. Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup. Biochemistry. 2014 Apr 29;53(16):2722-31. doi: 10.1021/bi500264p. Epub 2014 Apr, 15. PMID:24697546 doi:http://dx.doi.org/10.1021/bi500264p

4ihc, resolution 2.00Å

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