2ypr: Difference between revisions

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[[Image:2ypr.jpg|left|200px]]
==Crystal structure of the DNA binding ETS domain of human protein FEV==
 
<StructureSection load='2ypr' size='340' side='right' caption='[[2ypr]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
{{STRUCTURE_2ypr|  PDB=2ypr  |  SCENE=  }}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPR FirstGlance]. <br>
===Crystal structure of the DNA binding ETS domain of human protein FEV===
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ypr RCSB], [http://www.ebi.ac.uk/pdbsum/2ypr PDBsum]</span></td></tr>
 
</table>
==About this Structure==
== Disease ==
[[2ypr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA].  
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry.  A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.
== Function ==
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allerston, C K.]]
[[Category: Allerston, C K.]]

Revision as of 15:03, 29 October 2014

Crystal structure of the DNA binding ETS domain of human protein FEVCrystal structure of the DNA binding ETS domain of human protein FEV

Structural highlights

2ypr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[FEV_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Function

[FEV_HUMAN] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.[1]

References

  1. ↑ Maurer P, T'Sas F, Coutte L, Callens N, Brenner C, Van Lint C, de Launoit Y, Baert JL. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain. Oncogene. 2003 May 22;22(21):3319-29. PMID:12761502 doi:http://dx.doi.org/10.1038/sj.onc.1206572

2ypr, resolution 2.64Å

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