4ga7: Difference between revisions
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{{STRUCTURE_4ga7| PDB=4ga7 | SCENE= }} | {{STRUCTURE_4ga7| PDB=4ga7 | SCENE= }} | ||
===Crystal structure of human serpinB1 mutant=== | ===Crystal structure of human serpinB1 mutant=== | ||
{{ABSTRACT_PUBMED_23269243}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ILEU_HUMAN ILEU_HUMAN]] Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.<ref>PMID:11747453</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4ga7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA7 OCA]. | [[4ga7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA7 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023269243</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fan, Z.]] | [[Category: Fan, Z.]] | ||
Revision as of 07:10, 18 July 2013
Crystal structure of human serpinB1 mutantCrystal structure of human serpinB1 mutant
Template:ABSTRACT PUBMED 23269243
FunctionFunction
[ILEU_HUMAN] Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.[1]
About this StructureAbout this Structure
4ga7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. J Immunol. 2012 Dec 26. PMID:23269243 doi:10.4049/jimmunol.1202542