1ygo: Difference between revisions
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[[Image:1ygo.gif|left|200px]] | [[Image:1ygo.gif|left|200px]] | ||
'''Solution Structure of the pelle Death Domain''' | {{Structure | ||
|PDB= 1ygo |SIZE=350|CAPTION= <scene name='initialview01'>1ygo</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | |||
|GENE= pll ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]) | |||
}} | |||
'''Solution Structure of the pelle Death Domain''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1YGO is a [ | 1YGO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YGO OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of the isolated Pelle death domain., Moncrieffe MC, Stott KM, Gay NJ, FEBS Lett. 2005 Jul 18;579(18):3920-6. PMID:[http:// | Solution structure of the isolated Pelle death domain., Moncrieffe MC, Stott KM, Gay NJ, FEBS Lett. 2005 Jul 18;579(18):3920-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16004997 16004997] | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: anti-parallel 6 helix bundle]] | [[Category: anti-parallel 6 helix bundle]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:22:38 2008'' | ||
Revision as of 16:22, 20 March 2008
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| Gene: | pll (Drosophila melanogaster) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of the pelle Death Domain
OverviewOverview
The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.
About this StructureAbout this Structure
1YGO is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the isolated Pelle death domain., Moncrieffe MC, Stott KM, Gay NJ, FEBS Lett. 2005 Jul 18;579(18):3920-6. PMID:16004997
Page seeded by OCA on Thu Mar 20 15:22:38 2008