2zan: Difference between revisions
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{{STRUCTURE_2zan| PDB=2zan | SCENE= }} | {{STRUCTURE_2zan| PDB=2zan | SCENE= }} | ||
===Crystal structure of mouse SKD1/VPS4B ATP-form=== | ===Crystal structure of mouse SKD1/VPS4B ATP-form=== | ||
{{ABSTRACT_PUBMED_18796009}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/VPS4B_MOUSE VPS4B_MOUSE]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (By similarity).<ref>PMID:10393249</ref> <ref>PMID:10679028</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2zan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2zan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAN OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018796009</ref><references group="xtra"/> | <ref group="xtra">PMID:018796009</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Inoue, M.]] | [[Category: Inoue, M.]] | ||
[[Category: Kamikubo, H.]] | [[Category: Kamikubo, H.]] | ||