2k86: Difference between revisions
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{{STRUCTURE_2k86| PDB=2k86 | SCENE= }} | {{STRUCTURE_2k86| PDB=2k86 | SCENE= }} | ||
===Solution Structure of FOXO3a Forkhead domain=== | |||
{{ABSTRACT_PUBMED_18824006}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN]] Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN]] Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.<ref>PMID:10102273</ref><ref>PMID:16751106</ref><ref>PMID:21329882</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018824006</ref><references group="xtra"/> | <ref group="xtra">PMID:018824006</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ikura, M.]] | [[Category: Ikura, M.]] | ||