Sandbox Reserved 703: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Revision as of 02:52, 7 January 2013 view source Christine Ponkratz (talk \| contribs) 46 edits No edit summary ← Older edit		Revision as of 02:53, 7 January 2013 view source Christine Ponkratz (talk \| contribs) 46 edits No edit summary Newer edit →
Line 32:		Line 32:
	<scene name='Sandbox_Reserved_703/D61/1'>D61</scene> is the only dipolar acceptor group that makes a hydrogen bond with the only proton available on dibasic phosphate.		<scene name='Sandbox_Reserved_703/D61/1'>D61</scene> is the only dipolar acceptor group that makes a hydrogen bond with the only proton available on dibasic phosphate.

	The negative surface in the binding pocket and the D61 of the HPBP are involved in the specificity towards the phosphate. Due to the negative environment only anions perfectly matching the hydrogen bonds are able of binding. The D61 residue is responsible for the discrimination between phosphate and the very similar sulfate, which is missing the hydrogen needed for the bond with D61. <ref>PMID:16531243</ref>		The negative surface of the binding pocket and the D61 of the HPBP are involved in the specificity towards the phosphate. Due to the negative environment only anions perfectly matching the hydrogen bonds are able of binding. The D61 residue is responsible for the discrimination between phosphate and the very similar sulfate, which is missing the hydrogen needed for the bond with D61. <ref>PMID:16531243</ref>