Sandbox Reserved 713: Difference between revisions
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The differents domains involved into the Aβ dimerisation aren't yet wery well known, but it seems that E1 and E2 are playing a major role. E1 contains the copper-binding site domain and also the Growth Factor-like Domain, rather than E2 contains the Central APP domain. Those two regions are located in the extracellurlar space. <ref> PMID : 20400860 </ref> | The differents domains involved into the Aβ dimerisation aren't yet wery well known, but it seems that E1 and E2 are playing a major role. E1 contains the copper-binding site domain and also the Growth Factor-like Domain, rather than E2 contains the Central APP domain. Those two regions are located in the extracellurlar space. <ref> PMID : 20400860 </ref> | ||
If the CuBD (located in E1 region) does contribute to APP dimerisation without Cu ions, that | If the CuBD (located in E1 region) does contribute to APP dimerisation without Cu ions, that means that the Cu binding may reduce Aβ production, either by shifting the monomer-dimer equilibrium to favor monomer form, or by re-orienting the dimer form, which disfavours the Aβ production. <ref name="Molecular" /> | ||
=='''Additionnal Resources'''== | =='''Additionnal Resources'''== | ||