Sandbox Reserved 713: Difference between revisions
| Line 52: | Line 52: | ||
=='''Biological role'''== | =='''Biological role'''== | ||
2FKL | 2FKL belongs to the domain of APP which is able to bind Cu and zinc. Copper is an important metal to health. It acts as an indispensable catalytic and structural cofactor that drive many biological functions of our organism. But in particular situations like overcconcentration it can also become toxic for the cell. <ref name="Molecular" /> | ||
[[Image:CuI coordination.png | thumb | 220px | left | Fig.1: Cu(I) binding geometry]] | [[Image:CuI coordination.png | thumb | 220px | left | Fig.1: Cu(I) binding geometry]] | ||
| Line 67: | Line 67: | ||
In the <scene name='Sandbox_Reserved_713/2fk2_complex/1'>Cu(I) binding geometry</scene> (represented in grey in Fig.2)(PDB id [http://www.rcsb.org/pdb/explore.do?structureId=2fk2 2fk2]), there is no axial water molecules ; the site adopts also a distorted square planar arrangement which is unfavorable for Cu(I) suggesting that this states is not favorable and can lead to the tranfert of the Cu (I) to others proteins.In Fig.2 standart atomic colouring reprensents the Cu(II)binding form. | In the <scene name='Sandbox_Reserved_713/2fk2_complex/1'>Cu(I) binding geometry</scene> (represented in grey in Fig.2)(PDB id [http://www.rcsb.org/pdb/explore.do?structureId=2fk2 2fk2]), there is no axial water molecules ; the site adopts also a distorted square planar arrangement which is unfavorable for Cu(I) suggesting that this states is not favorable and can lead to the tranfert of the Cu (I) to others proteins.In Fig.2 standart atomic colouring reprensents the Cu(II)binding form. | ||
=='''Medical Implication'''== | =='''Medical Implication'''== | ||