1ypq: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ypq.png|left|200px]]
 {{STRUCTURE_1ypq|  PDB=1ypq  |  SCENE=  }}
+===Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex===
+{{ABSTRACT_PUBMED_15695803}}
-===Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex===
+==Disease==
+[[http://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN]] Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.<ref>PMID:12384789</ref><ref>PMID:12807963</ref><ref>PMID:15060104</ref><ref>PMID:15276231</ref><ref>PMID:15860461</ref>  Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.<ref>PMID:12384789</ref><ref>PMID:12807963</ref><ref>PMID:15060104</ref><ref>PMID:15276231</ref><ref>PMID:15860461</ref>
-{{ABSTRACT_PUBMED_15695803}}
+==Function==
+[[http://www.uniprot.org/uniprot/OLR1_HUMAN OLR1_HUMAN]] Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.<ref>PMID:9052782</ref><ref>PMID:11821063</ref><ref>PMID:12354387</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:015695803</ref><references group="xtra"/>
+<ref group="xtra">PMID:015695803</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Adsit, F G.]]