Sandbox Reserved 713: Difference between revisions
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As the interaction between copper ion and APP can modulate the production of Aβ peptide <ref name="Molecular"> PMID:18030462 </ref> and also the progression of Alzheimer disease, structural studies of the Cu-binding Domain of this protein give a lot of information for the development of novel therapeutics. | As the interaction between copper ion and APP can modulate the production of Aβ peptide <ref name="Molecular"> PMID:18030462 </ref> and also the progression of Alzheimer disease, structural studies of the Cu-binding Domain of this protein give a lot of information for the development of novel therapeutics. | ||
=='''Structure'''== | =='''Structure'''== | ||
<Structure load='2fkl' size=' | <Structure load='2fkl' size='400' align='left' background='none' scene='' caption='[[2fkl]]'/> | ||
The three dimensional structure of the Cu-Binding Domain was first determined by resonance multidimensional NMR spectroscopy <ref name="MolecularI"> PMID:12611883 </ref>. More recently, the determination of the crystallographic structure permits to define the molecular interaction between the Cu-Binding Domain and copper.<ref name="Molecular" /> | The three dimensional structure of the Cu-Binding Domain was first determined by resonance multidimensional NMR spectroscopy <ref name="MolecularI"> PMID:12611883 </ref>. More recently, the determination of the crystallographic structure permits to define the molecular interaction between the Cu-Binding Domain and copper.<ref name="Molecular" /> | ||