Sandbox Reserved 713: Difference between revisions
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This proteins plays a major role into the development of Alzheimer disease<ref> PMID:12399581 </ref>. APP cleavage by BACE and gamma secretase gives ended rise to the Aβ peptide, which forms at the end an aggregation of amyloid plaques <ref> PMID:2881207 </ref> . | This proteins plays a major role into the development of Alzheimer disease<ref> PMID:12399581 </ref>. APP cleavage by BACE and gamma secretase gives ended rise to the Aβ peptide, which forms at the end an aggregation of amyloid plaques <ref> PMID:2881207 </ref> . | ||
As the interaction between copper ion and APP can modulate the production of Aβ peptide | As the interaction between copper ion and APP can modulate the production of Aβ peptide <ref name="Molecular"> PMID:18030462</ref> and also the progression of Alzheimer disease, structural studies of the Cu-binding Domain of this protein give a lot of information for the development of novel therapeutics. | ||
=='''Structure'''== | =='''Structure'''== | ||
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=='''Biological role'''== | =='''Biological role'''== | ||
2FKL belong to the domain of APP which is able to bind Cu and zinc. Copper is an important metal to health. It acts as an indispensable catalytic and structural cofactor that drive many biological functions of our organism. But in particular situations like overcconcentration it can also become toxic for the cell. <ref | 2FKL belong to the domain of APP which is able to bind Cu and zinc. Copper is an important metal to health. It acts as an indispensable catalytic and structural cofactor that drive many biological functions of our organism. But in particular situations like overcconcentration it can also become toxic for the cell. <ref name="Molecular" /> | ||
[[Image:CuI coordination.png | thumb | 220px | right | texte ici]] | [[Image:CuI coordination.png | thumb | 220px | right | texte ici]] | ||
[[Image:CuII coordination complex.jpg | thumb | 220px | left| texte ici]] | [[Image:CuII coordination complex.jpg | thumb | 220px | left| texte ici]] | ||