Sandbox Reserved 713: Difference between revisions
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As the interaction between copper ion and APP can modulate the production of Aβ peptide <ref> PMID:18030462</ref> and also the progression of Alzheimer disease, structural studies of the Cu-binding Domain of this protein give a lot of information for the development of novel therapeutics. | As the interaction between copper ion and APP can modulate the production of Aβ peptide <ref> PMID:18030462</ref> and also the progression of Alzheimer disease, structural studies of the Cu-binding Domain of this protein give a lot of information for the development of novel therapeutics. | ||
=='''Structure'''== | =='''Structure'''== | ||
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In the Cu(I) binding geometry (represented in grey in Fig 2)(PDB id [http://www.rcsb.org/pdb/explore.do?structureId=2fk2 2fk2]), there is no axial water molecules ; the site adopts also a distorted square planar arrangement which is unfavorable for Cu(I) suggesting that this states is not favorable and can lead to the tranfert of the Cu (I) to others proteins.In Fig 2 standart atomic colouring reprensents the Cu(II)binding form. | In the Cu(I) binding geometry (represented in grey in Fig 2)(PDB id [http://www.rcsb.org/pdb/explore.do?structureId=2fk2 2fk2]), there is no axial water molecules ; the site adopts also a distorted square planar arrangement which is unfavorable for Cu(I) suggesting that this states is not favorable and can lead to the tranfert of the Cu (I) to others proteins.In Fig 2 standart atomic colouring reprensents the Cu(II)binding form. | ||
=='''Medical Implication'''== | =='''Medical Implication'''== | ||
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[http://www.rcsb.org/pdb/explore.do?structureId=2fk2 PDB file of 2fk2] <br/> | [http://www.rcsb.org/pdb/explore.do?structureId=2fk2 PDB file of 2fk2] <br/> | ||
[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001767/ Alzheimer disease] | [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001767/ Alzheimer disease] | ||
=='''References'''== | =='''References'''== | ||
<references/> | <references/> | ||
== '''Contributors''' == | === '''Contributors''' === | ||
Milène Walter, Andréa Mc Cann | Milène Walter, Andréa Mc Cann | ||