1uf7: Difference between revisions
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==Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valine== | |||
<StructureSection load='1uf7' size='340' side='right' caption='[[1uf7]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1uf7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UF7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDV:3-METHYL-2-UREIDO-BUTYRIC+ACID'>CDV</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1erz|1erz]], [[1uf4|1uf4]], [[1uf5|1uf5]], [[1uf8|1uf8]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-carbamoyl-D-amino-acid_hydrolase N-carbamoyl-D-amino-acid hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.77 3.5.1.77] </span></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uf7 RCSB], [http://www.ebi.ac.uk/pdbsum/1uf7 PDBsum]</span></td></tr> | ||
[[1uf7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF7 OCA]. | </table> | ||
[[Category: Agrobacterium sp | == Function == | ||
[[http://www.uniprot.org/uniprot/DCAS_AGRSK DCAS_AGRSK]] The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1uf7_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Agrobacterium sp]] | |||
[[Category: N-carbamoyl-D-amino-acid hydrolase]] | [[Category: N-carbamoyl-D-amino-acid hydrolase]] | ||
[[Category: Aoki, M | [[Category: Aoki, M]] | ||
[[Category: Hashimoto, H | [[Category: Hashimoto, H]] | ||
[[Category: Ikenaka, Y | [[Category: Ikenaka, Y]] | ||
[[Category: Morikawa, H | [[Category: Morikawa, H]] | ||
[[Category: Nakai, T | [[Category: Nakai, T]] | ||
[[Category: Sato, M | [[Category: Sato, M]] | ||
[[Category: Shimizu, T | [[Category: Shimizu, T]] | ||
[[Category: Takahashi, S | [[Category: Takahashi, S]] | ||
[[Category: D-amino acid]] | [[Category: D-amino acid]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: N-carbamyl-d-amino acid amidohydrolase]] | [[Category: N-carbamyl-d-amino acid amidohydrolase]] | ||
[[Category: N-carbamyl-d-valine]] | [[Category: N-carbamyl-d-valine]] | ||
Revision as of 10:57, 25 December 2014
Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valineCrystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valine
Structural highlights
Function[DCAS_AGRSK] The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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