1tx7: Difference between revisions

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Revision as of 15:24, 20 March 2008

File:1tx7.gif

, resolution 1.75Å

Ligands:

and

Activity:

Trypsin, with EC number 3.4.21.4

Coordinates:

save as pdb, mmCIF, xml

Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)

OverviewOverview

p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole.

About this StructureAbout this Structure

1TX7 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

An oxyanion-hole selective serine protease inhibitor in complex with trypsin., Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME, Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:11738605

Page seeded by OCA on Thu Mar 20 14:24:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1tx7.gif|left|200px]]<br /><applet load="1tx7" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1tx7.gif|left|200px]]
-caption="1tx7, resolution 1.75&Aring;" />
-'''Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)'''<br />
+ {{Structure
+|PDB= 1tx7 |SIZE=350|CAPTION= <scene name='initialview01'>1tx7</scene>, resolution 1.75&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=4CM:(4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC ACID'>4CM</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4]
+|GENE=
+}}
+'''Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-TX7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=4CM:'>4CM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TX7 OCA].
+TX7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TX7 OCA].
 ==Reference==
-An oxyanion-hole selective serine protease inhibitor in complex with trypsin., Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME, Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11738605 11738605]
+An oxyanion-hole selective serine protease inhibitor in complex with trypsin., Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME, Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11738605 11738605]
 [[Category: Bos taurus]]
 [[Category: Single protein]]
@@ Line 26: / Line 35: @@
 [[Category: trypsin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:18:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:24:23 2008''