Sandbox Reserved 708: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Noémie Kunkler, Fabienne Dricot

@@ Line 21: / Line 21: @@
 == Activity ==
-{{STRUCTURE_1j1c| PDB=1j1c | SCENE= Sandbox_Reserved_708/Complete_binary_complex/3 }}Since GSK-3 is constitutively active in most cell types, regulation of substrate phosphorylation occurs either by inactivation of GSK-3 or by changing substrate accessibility or recognition. The structure has provided insight into the preference of GSK-3 for primed, pre-phosphorylated substrates. There are numerous putative GSK-3 substrates with roles in a wide spectrum of cellular processes including: glycogen metabolism, transcription, translation, cytoskeletal regulation, intracellular vesicular transport, cell cycle progression, circadian rhythm regulation and apoptosis,<ref name ="GSK3 TTMTK"/>
+{{STRUCTURE_1j1c| PDB=1j1c | SCENE= Sandbox_Reserved_708/Complete_binary_complex/3 }}Since GSK-3 is constitutively active in most cell types, regulation of substrate phosphorylation occurs either by inactivation of GSK-3 or by changing substrate accessibility or recognition. The structure indicates the preference of GSK-3 for primed, pre-phosphorylated substrates. There are numerous putative GSK-3 substrates with roles in a wide spectrum of cellular processes including: glycogen metabolism, transcription, translation, cytoskeletal regulation, intracellular vesicular transport, cell cycle progression, circadian rhythm regulation and apoptosis,<ref name ="GSK3 TTMTK"/>
 The EC code indicates that GSK-3β belongs to two different classes,<ref>http://www.ebi.ac.uk/pdbsum/1j1c</ref>:
 *Enzyme classe 1 with [http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.7.11.1 E.C.2.7.11.1] it's a non-specific serine/threonine protein kinase