1tdw: Difference between revisions

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[[Image:1tdw.jpg|left|200px]]<br /><applet load="1tdw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tdw.jpg|left|200px]]
caption="1tdw, resolution 2.10&Aring;" />
 
'''Crystal structure of double truncated human phenylalanine hydroxylase BH4-responsive PKU mutant A313T.'''<br />
{{Structure
|PDB= 1tdw |SIZE=350|CAPTION= <scene name='initialview01'>1tdw</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FE:FE (III) ION'>FE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]
|GENE= PAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of double truncated human phenylalanine hydroxylase BH4-responsive PKU mutant A313T.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TDW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDW OCA].  
1TDW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDW OCA].  


==Reference==
==Reference==
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations., Erlandsen H, Pey AL, Gamez A, Perez B, Desviat LR, Aguado C, Koch R, Surendran S, Tyring S, Matalon R, Scriver CR, Ugarte M, Martinez A, Stevens RC, Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16903-8. Epub 2004 Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15557004 15557004]
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations., Erlandsen H, Pey AL, Gamez A, Perez B, Desviat LR, Aguado C, Koch R, Surendran S, Tyring S, Matalon R, Scriver CR, Ugarte M, Martinez A, Stevens RC, Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16903-8. Epub 2004 Nov 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15557004 15557004]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine 4-monooxygenase]]
[[Category: Phenylalanine 4-monooxygenase]]
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[[Category: phenylalanine catabolism]]
[[Category: phenylalanine catabolism]]


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