Sandbox Reserved 718: Difference between revisions
| Line 9: | Line 9: | ||
Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA‑binding motifs: a cold shock domain and a pair of retroviral‑type CCHC zinc fingers. | Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA‑binding motifs: a cold shock domain and a pair of retroviral‑type CCHC zinc fingers. | ||
Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA binding motifs: a cold shock domain and a pair of retroviral type CCHC zinc fingers. It plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, Lin28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. Mammals have two homologs, Lin28a and Lin28b. These two homologs are found from worms to humans | Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA binding motifs: a cold shock domain and a pair of retroviral type CCHC zinc fingers. It plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, Lin28 is known to repress maturation of let-7 microRNAs and enhance translation of certain mRNAs. Mammals have two homologs, Lin28a and Lin28b. These two homologs are found from worms to humans ; Balzer and Moss, 2007).<ref>Jun Cho, Hyeshik Chang, S. Chul Kwon, Baekgyu Kim, Yoosik Kim, Junho Choe, Minju Ha, Yoon Ki Kim, and V. Narry Kim: LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells. In: Cell 151, S. 765–777, November 9, 2012</ref> Lin28a is highly expressed in embryonic stem cells (ESCs) and was shown as one of the four factors that convert fibroblasts into induced pluripotent stem cells (Yu et al., 2007). | ||
At the molecular level, Lin28 acts as a suppressor of let-7 microRNA biogenesis (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008). In the nucleus, Lin28 binds to the primary transcript of let-7 (pri-let-7) and prevents its processing by RNase III DROSHA (Newman et al., 2008; Viswanathan et al., 2008). In the cytoplasm, it interacts with the precursor form of let-7 (pre-let-7) and interferes with pre-let-7 processing (Heo et al., 2008; Rybak et al., 2008). Lin28 recruits TUTase 4 (ZCCHC11) to induce oligo-uridylation | At the molecular level, Lin28 acts as a suppressor of let-7 microRNA biogenesis (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008). In the nucleus, Lin28 binds to the primary transcript of let-7 (pri-let-7) and prevents its processing by RNase III DROSHA (Newman et al., 2008; Viswanathan et al., 2008). In the cytoplasm, it interacts with the precursor form of let-7 (pre-let-7) and interferes with pre-let-7 processing (Heo et al., 2008; Rybak et al., 2008). Lin28 recruits TUTase 4 (ZCCHC11) to induce oligo-uridylation | ||