Sandbox Reserved 712: Difference between revisions
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== '''Description''' == | == '''Description''' == | ||
<scene name='Sandbox_Reserved_712/3ggu/1'>3ggu</scene> is a drug resistant HIV protease. Shown is a patient's variant in complex with [[darunavir]]. | <scene name='Sandbox_Reserved_712/3ggu/1'>3ggu</scene> is a drug resistant [[HIV-1 protease]]. Shown is a patient's variant in complex with [[darunavir]]. | ||
[[HIV-1 protease]] (PR) are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process [[Hiv-1 gag]] & gap - polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | [[HIV-1 protease]] (PR) are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process [[Hiv-1 gag]] & gap - polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | ||
HIV | [[HIV-1 protease]] contain a highly conserved region Asp - Thr - Gly (<scene name='Sandbox_Reserved_712/Activesiteasp25/1'>Asp25</scene>, <scene name='Sandbox_Reserved_712/Activesitethr26/1'>Thr26</scene> and | ||
<scene name='Sandbox_Reserved_712/Activesitegly27/2'>Gly27</scene>), with the aspartic residue being the <scene name='Sandbox_Reserved_712/Activesite/2'>active site</scene> | <scene name='Sandbox_Reserved_712/Activesitegly27/2'>Gly27</scene>), with the aspartic residue being the <scene name='Sandbox_Reserved_712/Activesite/2'>active site</scene> | ||
in the aspartyl protease.<ref> PMID:3290901 </ref> | in the aspartyl protease.<ref> PMID:3290901 </ref> | ||