Sandbox Reserved 708: Difference between revisions
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== Descritpion == | == Descritpion == | ||
The Glycogen Synthase Kinase 3 beta- GSK3 beta, also known as the tau protein kinase I, is a serine protein kinase that participates in many different pathways regulating critical cellular functions as structure, gene expression, mobility, and apoptosis. GSK-3 phosphorylates a large number of substrates and is himself regulated by phosphorylation. | The Glycogen Synthase Kinase 3 beta- GSK3 beta, also known as the tau protein kinase I, is a serine protein kinase that participates in many different pathways regulating critical cellular functions as structure, gene expression, mobility, and apoptosis. GSK-3 phosphorylates a large number of substrates and is himself regulated by phosphorylation. | ||
GSK-3 is implicated in several diseases like Alzheimer’s disease, diabetes, mood disorders and cancer,<ref>Neurochem Res. 2007; 32(4-5): 577–595. Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics, Richard S. Jope,* Christopher J. Yuskaitis, and Eléonore Beurel</ref>. In the Alzheimer’s disease, it is thought to be tied to the process of the hyperphosphorylation of tau proteins which leads to the formation of neurofibrillary tangles and to the build up of Amyloid-β (Aβ) deposits. Dephosphorylated tau binds normally to microtubules, one of the major components of the neuronal cytoskeleton that contributes to the proper function of neurons. | GSK-3 is implicated in several diseases like Alzheimer’s disease, diabetes, mood disorders and cancer,<ref>Neurochem Res. 2007; 32(4-5): 577–595. Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics, Richard S. Jope,* Christopher J. Yuskaitis, and Eléonore Beurel</ref>. In the Alzheimer’s disease, it is thought to be tied to the process of the hyperphosphorylation of tau proteins which leads to the formation of neurofibrillary tangles and to the build up of Amyloid-β (Aβ) deposits. Dephosphorylated tau binds normally to microtubules, one of the major components of the neuronal cytoskeleton that contributes to the proper function of neurons. | ||
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== Structure == | == Structure == | ||
[[Image:Ramachandran plot 1j1c.gif]],<ref>http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1j1c&template=procheck_summary.html</ref> | |||
These are the <scene name='Sandbox_Reserved_708/Catalytic_site/5'>amino acids</scene> engaged in the catalytic site of the protein, they are polar and localised in 3' end (Asp-181, Lys-183, Gln-185, Asn-186 and Ser-219. | These are the <scene name='Sandbox_Reserved_708/Catalytic_site/5'>amino acids</scene> engaged in the catalytic site of the protein, they are polar and localised in 3' end (Asp-181, Lys-183, Gln-185, Asn-186 and Ser-219. | ||