1shc: Difference between revisions
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'''SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE''' | {{Structure | ||
|PDB= 1shc |SIZE=350|CAPTION= <scene name='initialview01'>1shc</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= PTB DOMAIN OF SHC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | |||
}} | |||
'''SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1SHC is a [ | 1SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA]. | ||
==Reference== | ==Reference== | ||
Structure and ligand recognition of the phosphotyrosine binding domain of Shc., Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW, Nature. 1995 Dec 7;378(6557):584-92. PMID:[http:// | Structure and ligand recognition of the phosphotyrosine binding domain of Shc., Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW, Nature. 1995 Dec 7;378(6557):584-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8524391 8524391] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: phosphotyrosine binding domain (ptb)]] | [[Category: phosphotyrosine binding domain (ptb)]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:04:58 2008'' | ||
Revision as of 15:05, 20 March 2008
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| Gene: | PTB DOMAIN OF SHC (Escherichia coli) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
OverviewOverview
The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally similar to pleckstrin homology domains (a beta-sandwich capped by an alpha-helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization.
DiseaseDisease
Known diseases associated with this structure: Insensitivity to pain, congenital, with anhidrosis OMIM:[191315], Medullary thyroid carcinoma, familial OMIM:[191315]
About this StructureAbout this Structure
1SHC is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
Structure and ligand recognition of the phosphotyrosine binding domain of Shc., Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW, Nature. 1995 Dec 7;378(6557):584-92. PMID:8524391
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