SandboxPKA: Difference between revisions
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- The '''activation loop''' contains Tyr412 responsible of activation of kinase activity. | - The '''activation loop''' contains Tyr412 responsible of activation of kinase activity. | ||
- The '''myristoyl group''' complement activation loop in turning on and off c-abl protein. It has been shown to be the key regulator of this kinase. | - The '''myristoyl group''' complement activation loop in turning on and off c-abl protein. It has been shown to be the key regulator of this kinase. | ||
To see <scene name='Dasatinib/Mtot/2'>morphs of the movement</scene> of key structural elements Click: <scene name='Dasatinib/Mdfg/3'>DFG Movement</scene>, <scene name='Dasatinib/Mpl/4'>P-Loop Movement</scene>, & the <scene name='Dasatinib/Mact/1'>Activation Loop Movement</scene>. | |||
==='''Catalytic domain'''=== | |||
<scene name='SandboxPKA/Catalytic_domain/2'>See catalytic domain</scene> | <scene name='SandboxPKA/Catalytic_domain/2'>See catalytic domain</scene> | ||