1s12: Difference between revisions

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Revision as of 14:59, 20 March 2008

File:1s12.gif

, resolution 2.00Å

Ligands:

Coordinates:

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Crystal structure of TM1457

OverviewOverview

The crystal structure of a hypothetical protein, TM1457, from Thermotoga maritima has been determined at 2.0A resolution. TM1457 belongs to the DUF464 family (57 members) for which there is no known function. The structure shows that it is composed of two helices in contact with one side of a five-stranded beta-sheet. Two identical monomers form a pseudo-dimer in the asymmetric unit. There is a large cleft between the first alpha-helix and the second beta-strand. This cleft may be functionally important, since the two highly conserved motifs, GHA and VCAXV(S/T), are located around the cleft. A structural comparison of TM1457 with known protein structures shows the best hit with another hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they share low structural similarity. Therefore, TM1457 still retains a unique topology and reveals a novel fold.

About this StructureAbout this Structure

1S12 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:16242963

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1s12.gif|left|200px]]<br /><applet load="1s12" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1s12.gif|left|200px]]
-caption="1s12, resolution 2.00&Aring;" />
-'''Crystal structure of TM1457'''<br />
+ {{Structure
+|PDB= 1s12 |SIZE=350|CAPTION= <scene name='initialview01'>1s12</scene>, resolution 2.00&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal structure of TM1457'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-S12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA].
+S12 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA].
 ==Reference==
-Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16242963 16242963]
+Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16242963 16242963]
 [[Category: Single protein]]
 [[Category: Thermotoga maritima]]
@@ Line 27: / Line 36: @@
 [[Category: protein structure initiative]]
 [[Category: psi]]
-[[Category: structural genomics]]
+[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:59:00 2008''