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Structure of E. coli DnaC helicase loader: Difference between revisions

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Thus, there is reason for optimism that either a crystal structure, or a more suitable template for homology modeling, might be forthcoming.
Thus, there is reason for optimism that either a crystal structure, or a more suitable template for homology modeling, might be forthcoming.
==ConSurf Coloring Script==
For an explanation of the evolutionary conservation results, see above.
The script below is from the 2012 analysis<ref name='2012consurf' />. It can be run in Jmol to color the amino acids of DnaC by evolutionary conservation.
<pre>
select all
color [200,200,200]
select PHE57
color [255,255,150]
spacefill
define CON10 selected
select ILE62, ASN73, GLY106, GLY109, THR110, GLY111, LYS112, HIS114, LEU115
select selected or ALA116, ALA118, GLU153, LEU165, LEU166, ASP169, GLU170
select selected or GLY172, ASP189, ARG191, ASN203, ARG216, ASP219, ARG220
select selected or TRP233, SER235, ARG237
color [160,37,96]
spacefill
define CON9 selected
select ARG55, SER60, GLY61, LEU65, PHE71, TYR74, ALA84, VAL92, PHE95, ASN113
select selected or ILE119, LEU123, VAL130, THR134, THR145, VAL163, ILE168
select selected or GLN174, SER177, GLU180, ILE187, SER192, PRO197, THR198
select selected or THR202, GLY214, MET221, SER226, PHE231
color [240,125,171]
spacefill
define CON8 selected
select HIS66, GLN81, PHE102, VAL135, SER140, LYS143, SER152, LEU156, ASP164
select selected or VAL167, ILE171, ILE184, ASN185, VAL188, GLY199, LEU213
color [250,201,222]
spacefill
define CON7 selected
select THR56, ARG59, CYS69, SER70, ALA88, TYR91, ILE99, SER101, PHE104, SER105
select selected or ALA117, CYS120, ASN121, LEU124, GLY127, SER129, ILE133
select selected or ALA136, ASP137, ILE138, MET139, PHE146, ILE183, GLN186
select selected or ARG190, SER193, MET200, LEU201, SER204, LEU223, GLY224
select selected or ASN225, VAL229
color [252,237,244]
spacefill
define CON6 selected
select ASN58, ARG63, ASN68, VAL76, GLY80, LEU85, ASN98, ALA100, ILE103, LEU131
select selected or MET142, LEU157, LEU160, SER161, VAL182, SER194, ASN205
select selected or MET209, VAL217, TYR236
color [255,255,255]
spacefill
define CON5 selected
select ARG89, GLU94, PRO108, SER149, GLU154, LYS178, TYR179, LYS181, ARG196
select selected or GLU215, LEU227
color [234,255,255]
spacefill
define CON4 selected
select PRO64, GLN67, GLU72, CYS78, MET82, ILE132, GLU176, GLU208, ASN232
color [215,255,255]
spacefill
define CON3 selected
select GLN90, ARG126, ALA141, VAL173, LYS195
color [140,255,255]
spacefill
define CON2 selected
select ARG75, GLU77, GLU79, ASN83, SER86, LYS87, GLU93, ASP96, GLY97, LYS107
select selected or GLU122, LEU125, LYS128, ASP144, ARG147, ASN148, GLY150
select selected or THR151, GLN155, ASN158, ASP159, ASN162, THR175, MET206
select selected or GLU207, THR210, LYS211, LEU212, MET218, ARG222, TRP228
select selected or ILE230, ASP234
color [16,200,209]
spacefill
define CON1 selected
</pre>


==3D structures of DnaC helicase loader==
==3D structures of DnaC helicase loader==

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Eric Martz, David Canner, Michal Harel, Alexander Berchansky, Joel L. Sussman
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