1qqp: Difference between revisions
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[[Image:1qqp.gif|left|200px]] | [[Image:1qqp.gif|left|200px]] | ||
'''FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.''' | {{Structure | ||
|PDB= 1qqp |SIZE=350|CAPTION= <scene name='initialview01'>1qqp</scene>, resolution 1.90Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QQP is a [ | 1QQP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus Foot-and-mouth disease virus]. This structure supersedes the now removed PDB entry 1FHP. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQP OCA]. | ||
==Reference== | ==Reference== | ||
The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex., Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI, EMBO J. 1999 Feb 1;18(3):543-54. PMID:[http:// | The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex., Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI, EMBO J. 1999 Feb 1;18(3):543-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9927414 9927414] | ||
[[Category: Foot-and-mouth disease virus]] | [[Category: Foot-and-mouth disease virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
[[Category: virus]] | [[Category: virus]] | ||
[[Category: virus-receptor interactions/protein-carbohydrate | [[Category: virus-receptor interactions/protein-carbohydrate interaction]] | ||
[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:23 2008'' | ||
Revision as of 14:41, 20 March 2008
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FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.
OverviewOverview
Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif of sulfated sugars. The binding site is a shallow depression on the virion surface, located at the junction of the three major capsid proteins, VP1, VP2 and VP3. Two pre-formed sulfate-binding sites control receptor specificity. Residue 56 of VP3, an arginine in this virus, is critical to this recognition, forming a key component of both sites. This residue is a histidine in field isolates of the virus, switching to an arginine in adaptation to tissue culture, forming the high affinity heparan sulfate-binding site. We postulate that this site is a conserved feature of FMDVs, such that in the infected animal there is a biological advantage to low affinity, or more selective, interactions with glycosaminoglycan receptors.
About this StructureAbout this Structure
1QQP is a Single protein structure of sequence from Foot-and-mouth disease virus. This structure supersedes the now removed PDB entry 1FHP. Full crystallographic information is available from OCA.
ReferenceReference
The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex., Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI, EMBO J. 1999 Feb 1;18(3):543-54. PMID:9927414
Page seeded by OCA on Thu Mar 20 13:41:23 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Foot-and-mouth disease virus
- Single protein
- Abu-Ghazaleh, R.
- Blakemore, W E.
- Ellard, F M.
- Fry, E E.
- Jackson, T.
- King, A M.Q.
- Lea, S M.
- Newman, J W.I.
- Samuel, A.
- Stuart, D I.
- Heparan sulphate
- Icosahedral virus
- Virus
- Virus-receptor interactions/protein-carbohydrate interaction
- Virus/viral protein