1q69: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1q69.gif|left|200px]]< | [[Image:1q69.gif|left|200px]] | ||
'''Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments''' | {{Structure | ||
|PDB= 1q69 |SIZE=350|CAPTION= <scene name='initialview01'>1q69</scene> | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= CD8A OR MAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==Disease== | ==Disease== | ||
Known diseases associated with this structure: | Known diseases associated with this structure: Megakaryoblastic leukemia, acute OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606078 606078]], SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]] | ||
==About this Structure== | ==About this Structure== | ||
1Q69 is a [ | 1Q69 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q69 OCA]. | ||
==Reference== | ==Reference== | ||
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http:// | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14500983 14500983] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 27: | Line 36: | ||
[[Category: zinc coordination]] | [[Category: zinc coordination]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:29 2008'' | ||
Revision as of 14:33, 20 March 2008
| |||||||
| Ligands: | |||||||
| Gene: | CD8A OR MAL (Homo sapiens), LCK (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments
OverviewOverview
The T cell coreceptors CD4 and CD8 both associate via their cytoplasmic tails with the N-terminus of the Src-family tyrosine kinase Lck. These interactions require zinc and are critical for T cell development and activation. We examined the folding and solution structures of ternary CD4-Lck-Zn2+ and CD8alpha-Lck-Zn2+ complexes. The coreceptor tails and the Lck N-terminus are unstructured in isolation but assemble in the presence of zinc to form compactly folded heterodimeric domains. The cofolded complexes have similar "zinc clasp" cores that are augmented by distinct structural elements. A dileucine motif required for clathrin-mediated endocytosis of CD4 is masked by Lck.
DiseaseDisease
Known diseases associated with this structure: Megakaryoblastic leukemia, acute OMIM:[606078], SCID due to LCK deficiency OMIM:[153390]
About this StructureAbout this Structure
1Q69 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:14500983
Page seeded by OCA on Thu Mar 20 13:33:29 2008