Exonuclease: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Revision as of 14:13, 30 October 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 14:15, 30 October 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
Line 1:		Line 1:
	{{STRUCTURE_1fxx\| PDB=1fxx \| SIZE=400\| SCENE= \|right\|CAPTION=E. coli exonuclease V complex with ~~DNA hairpin~~, [[1fxx]] }}		{{STRUCTURE_1fxx\| PDB=1fxx \| SIZE=400\| SCENE= \|right\|CAPTION=E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion, [[1fxx]] }}

	'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII. ExN-I cleaves single-stranded DNA; ExN-II is associated with DNA polymerase; ExN-III cleaves double-stranded DNA; ExN-IV cleavage results in nucleoside monophosphate; ExN-V cleaves linear double-stranded DNA; ExN-VIII requires a free 5’ OH group for reacting. ExN were found in human and yeast as well.		'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII. ExN-I cleaves single-stranded DNA; ExN-II is associated with DNA polymerase; ExN-III cleaves double-stranded DNA; ExN-IV cleavage results in nucleoside monophosphate; ExN-V cleaves linear double-stranded DNA; ExN-VIII requires a free 5’ OH group for reacting. ExN were found in human and yeast as well.