4hhf: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4hhf|  PDB=4hhf  |  SCENE=  }}
+===Crystal Structure of chemically synthesized scorpion alpha-toxin OD1===
+{{ABSTRACT_PUBMED_23527544}}
-The entry 4hhf is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/SCX1_ODODO SCX1_ODODO]] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Mammalian sodium channels Nav1.5/SCN2A (only at micromolar concentrations), Nav1.7/SCN9A (EC(50)=4.5 nM) and insect sodium channel para/tipE (EC(50)=80 nM) are affected by this toxin, whereas mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.<ref>PMID:16038905</ref> <ref>PMID:16641312</ref>
-Authors: Wang, C.I.A., Lewis, R.J., Alewood, P.F., Durek, T.
+==About this Structure==
+[[4hhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHF OCA].
-Description: Crystal Structure of chemically synthesized scorpion alpha-toxin OD1
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Alewood, P F.]]
+[[Category: Durek, T.]]
+[[Category: Lewis, R J.]]
+[[Category: Wang, C I.A.]]
+[[Category: 1 6]]
+[[Category: 1 7]]
+[[Category: C-terminally amidated]]
+[[Category: Gating modulator]]
+[[Category: Inhibition of fast channel inactivation]]
+[[Category: Scorpion long-chain alpha-toxin]]
+[[Category: Toxin]]
+[[Category: Venom gland]]
+[[Category: Voltage-gated sodium channels 1 4]]