1p0r: Difference between revisions
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'''Solution Structure of UBL5 a human Ubiquitin-Like Protein''' | {{Structure | ||
|PDB= 1p0r |SIZE=350|CAPTION= <scene name='initialview01'>1p0r</scene> | |||
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'''Solution Structure of UBL5 a human Ubiquitin-Like Protein''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1P0R is a [ | 1P0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0R OCA]. | ||
==Reference== | ==Reference== | ||
Structural analysis of UBL5, a novel ubiquitin-like modifier., McNally T, Huang Q, Janis RS, Liu Z, Olejniczak ET, Reilly RM, Protein Sci. 2003 Jul;12(7):1562-6. PMID:[http:// | Structural analysis of UBL5, a novel ubiquitin-like modifier., McNally T, Huang Q, Janis RS, Liu Z, Olejniczak ET, Reilly RM, Protein Sci. 2003 Jul;12(7):1562-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12824502 12824502] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ubiquitin-like fold]] | [[Category: ubiquitin-like fold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:18:14 2008'' | ||
Revision as of 14:18, 20 March 2008
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Solution Structure of UBL5 a human Ubiquitin-Like Protein
OverviewOverview
UBL5 is a widely expressed human protein that is strongly conserved across phylogeny. Orthologs of UBL5 occur in every eukaryotic genome characterized to date. The yeast ortholog of UBL5, HUB1, was reported to be a ubiquitin-like protein modifier important for modulation of protein function. However, unlike ubiquitin and all other ubiquitin-like modifiers, UBL5 and its yeast ortholog HUB1 both contain a C-terminal di-tyrosine motif followed by a single variable residue instead of the characteristic di-glycine found in all other ubiquitin-like modifiers. Here we describe the three-dimensional structure of UBL5 determined by NMR. The overall structure of the protein was found to be very similar to ubiquitin despite the low approximately 25% residue similarity. The signature C-terminal di-tyrosine residues in UBL5 are involved in the final beta sheet of the protein. This is very different to the di-glycine motif found in ubiquitin, which extends beyond the final beta sheet. In addition, we have confirmed an earlier report of an interaction between UBL5 and the cyclin-like kinase, CLK4, which we have determined is specific and does not extend to other cyclin-like kinase family members.
About this StructureAbout this Structure
1P0R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structural analysis of UBL5, a novel ubiquitin-like modifier., McNally T, Huang Q, Janis RS, Liu Z, Olejniczak ET, Reilly RM, Protein Sci. 2003 Jul;12(7):1562-6. PMID:12824502
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