1opg: Difference between revisions

Revision as of 14:13, 20 March 2008

, resolution 2.Å

Coordinates:

OPG2 FAB FRAGMENT

OverviewOverview

Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.

About this StructureAbout this Structure

1OPG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site., Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR, J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:7836460

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1opg.gif|left|200px]]<br /><applet load="1opg" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1opg.gif|left|200px]]
-caption="1opg, resolution 2.&Aring;" />
-'''OPG2 FAB FRAGMENT'''<br />
+ {{Structure
+|PDB= 1opg |SIZE=350|CAPTION= <scene name='initialview01'>1opg</scene>, resolution 2.&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''OPG2 FAB FRAGMENT'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-OPG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
+OPG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
 ==Reference==
-Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site., Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR, J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7836460 7836460]
+Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site., Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR, J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7836460 7836460]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
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 [[Category: cell adhesion molecule]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:20:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:13:52 2008''