1anp: Difference between revisions

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-[[Image:1anp.png|left|200px]]
 {{STRUCTURE_1anp|  PDB=1anp  |  SCENE=  }}
+===SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR===
+{{ABSTRACT_PUBMED_8043577}}
-===SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR===
+==Disease==
+[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[http://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
-{{ABSTRACT_PUBMED_8043577}}
+==Function==
+[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
 ==About this Structure==
 [[1anp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANP OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cunningham, B C.]]