2p5n: Difference between revisions
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{{STRUCTURE_2p5n| PDB=2p5n | SCENE= }} | {{STRUCTURE_2p5n| PDB=2p5n | SCENE= }} | ||
===Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH=== | ===Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH=== | ||
{{ABSTRACT_PUBMED_17909281}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AK1CL_MOUSE AK1CL_MOUSE]] NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids.<ref>PMID:15577209</ref> <ref>PMID:16018803</ref> <ref>PMID:17034817</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2p5n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2p5n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P5N OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017909281</ref><references group="xtra"/> | <ref group="xtra">PMID:017909281</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Dhagat, U.]] | [[Category: Dhagat, U.]] | ||
[[Category: El-Kabbani, O.]] | [[Category: El-Kabbani, O.]] | ||