1nqy: Difference between revisions
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[[Image:1nqy.jpg|left|200px]] | [[Image:1nqy.jpg|left|200px]] | ||
'''The structure of a CoA pyrophosphatase from D. Radiodurans''' | {{Structure | ||
|PDB= 1nqy |SIZE=350|CAPTION= <scene name='initialview01'>1nqy</scene>, resolution 2.09Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Nucleotide_diphosphatase Nucleotide diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.9 3.6.1.9] | |||
|GENE= Dr1184 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 Deinococcus radiodurans]) | |||
}} | |||
'''The structure of a CoA pyrophosphatase from D. Radiodurans''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1NQY is a [ | 1NQY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQY OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family., Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM, J Bacteriol. 2003 Jul;185(14):4110-8. PMID:[http:// | Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family., Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM, J Bacteriol. 2003 Jul;185(14):4110-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837785 12837785] | ||
[[Category: Deinococcus radiodurans]] | [[Category: Deinococcus radiodurans]] | ||
[[Category: Nucleotide diphosphatase]] | [[Category: Nucleotide diphosphatase]] | ||
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[[Category: pyrophosphatase]] | [[Category: pyrophosphatase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:00:35 2008'' | ||
Revision as of 14:00, 20 March 2008
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| , resolution 2.09Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | Dr1184 (Deinococcus radiodurans) | ||||||
| Activity: | Nucleotide diphosphatase, with EC number 3.6.1.9 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The structure of a CoA pyrophosphatase from D. Radiodurans
OverviewOverview
Gene Dr1184 from Deinococcus radiodurans codes for a Nudix enzyme (DR-CoAse) that hydrolyzes the pyrophosphate moiety of coenzyme A (CoA). Nudix enzymes with the same specificity have been found in yeast, humans, and mice. The three-dimensional structure of DR-CoAse, the first of a Nudix hydrolase with this specificity, reveals that this enzyme contains, in addition to the fold observed in other Nudix enzymes, insertions that are characteristic of a CoA-hydrolyzing Nudix subfamily. The structure of the complex of the enzyme with Mg(2+), its activating cation, reveals the position of the catalytic site. A helix, part of the N-terminal insertion, partially occludes the binding site and has to change its position to permit substrate binding. Comparison of the structure of DR-CoAse to those of other Nudix enzymes, together with the location in the structure of the sequence characteristic of CoAses, suggests a mode of binding of the substrate to the enzyme that is compatible with all available data.
About this StructureAbout this Structure
1NQY is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.
ReferenceReference
Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family., Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM, J Bacteriol. 2003 Jul;185(14):4110-8. PMID:12837785
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