2nsm: Difference between revisions
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{{STRUCTURE_2nsm| PDB=2nsm | SCENE= }} | {{STRUCTURE_2nsm| PDB=2nsm | SCENE= }} | ||
===Crystal structure of the human carboxypeptidase N (Kininase I) catalytic domain=== | |||
{{ABSTRACT_PUBMED_17157876}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN]] Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:[http://omim.org/entry/212070 212070]]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.<ref>PMID:12560874</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN]] Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 16: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017157876</ref><references group="xtra"/> | <ref group="xtra">PMID:017157876</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Lysine carboxypeptidase]] | [[Category: Lysine carboxypeptidase]] | ||
Revision as of 12:54, 24 March 2013
Crystal structure of the human carboxypeptidase N (Kininase I) catalytic domainCrystal structure of the human carboxypeptidase N (Kininase I) catalytic domain
Template:ABSTRACT PUBMED 17157876
DiseaseDisease
[CBPN_HUMAN] Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.[1]
FunctionFunction
[CBPN_HUMAN] Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
About this StructureAbout this Structure
2nsm is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Keil C, Maskos K, Than M, Hoopes JT, Huber R, Tan F, Deddish PA, Erdos EG, Skidgel RA, Bode W. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. J Mol Biol. 2007 Feb 16;366(2):504-16. Epub 2006 Nov 11. PMID:17157876 doi:10.1016/j.jmb.2006.11.025
- ↑ Cao H, Hegele RA. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. J Hum Genet. 2003;48(1):20-2. PMID:12560874 doi:10.1007/s100380300003