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==Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor== | |||
<StructureSection load='3isn' size='340' side='right' caption='[[3isn]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3isn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ISN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDM:6-ETHENYL-N,N-DIMETHYL-2-(METHYLSULFONYL)PYRIMIDIN-4-AMINE'>EDM</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ith|3ith]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12721 Human immunodeficiency virus])</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3isn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3isn RCSB], [http://www.ebi.ac.uk/pdbsum/3isn PDBsum]</span></td></tr> | ||
[[3isn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISN OCA]. | </table> | ||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isn_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Reverse transcriptase|Reverse transcriptase]] | *[[Reverse transcriptase|Reverse transcriptase]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human immunodeficiency virus]] | [[Category: Human immunodeficiency virus]] | ||
[[Category: Bec, G | [[Category: Bec, G]] | ||
[[Category: Botta, M | [[Category: Botta, M]] | ||
[[Category: Dumas, P | [[Category: Dumas, P]] | ||
[[Category: Ennifar, E | [[Category: Ennifar, E]] | ||
[[Category: Freisz, S | [[Category: Freisz, S]] | ||
[[Category: Radi, M | [[Category: Radi, M]] | ||
[[Category: Hiv-1]] | [[Category: Hiv-1]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 12:36, 8 December 2014
Crystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitorCrystal structure of HIV-1 RT bound to A 6-vinylpyrimidine inhibitor
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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