3sjv: Difference between revisions

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OCA

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-[[Image:3sjv.png|left|200px]]
 {{STRUCTURE_3sjv|  PDB=3sjv  |  SCENE=  }}
+===Crystal structure of the RL42 TCR in complex with HLA-B8-FLR===
+{{ABSTRACT_PUBMED_22140258}}
-===Crystal structure of the RL42 TCR in complex with HLA-B8-FLR===
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
-{{ABSTRACT_PUBMED_22140258}}
+==Function==
+[[http://www.uniprot.org/uniprot/1B08_HUMAN 1B08_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/EBNA3_EBVG EBNA3_EBVG]] Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop (By similarity). [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 ==About this Structure==
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 ==See Also==
 *[[Beta-2 microglobulin|Beta-2 microglobulin]]
+*[[T-cell receptor|T-cell receptor]]
 ==Reference==
-<ref group="xtra">PMID:022140258</ref><references group="xtra"/>
+<ref group="xtra">PMID:022140258</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Burrows, S R.]]